Endocrine Abstracts

Introduction: With a prevalence of about one in 3000 newborns, congenital hypothyroidism (CH) is the leading cause of preventable mental retardation and growth failure. The objective of this work is to clarify the contribution of thyroid scintigraphy (TS) using technetium 99 m for the diagnosis of CH and this through the experience of the nuclear medicine department in Sahloul university Hospital.Materials and methods: This is a retrospective study inclu...

Introduction: Multiple primary cancers are a rare entity; however their incidence is increasing due to advances in diagnostic methods and surveillance strategies. The coexistence in the same patient of several primary malignant tumors has been described in the literature with a frequency varying from 5.5% to 8.5%.The aim of this observation is to report a case associating 3 neoplasias:medullary thyroid carcinoma (MTC), papillary thyroid carcinoma (PTC) a...

Introduction: Adrenal hemangioma (AH) is a benign vascular tumor of the adrenal gland. The adrenal site of an hemangioma is extremely rare occurring only in 0.01% of cases and accounts for 63 reported cases in the literature. AH are often discovered as incidentalomas either by imaging studies or histologic examination. The role of computed tomography (CT) scan and Magnetic resonance imaging (MRI) is important for the differential diagnosis.Case report: W...

Introduction: VonHippel Lindau (VHL) disease is an autosomal dominant disorder, responsible of the occurrence of multiple endocrine and non-endocrine lesions. When it comes to this hereditary syndrom., pheochromocytoma and pancreatic neuroendocrine tumors (pNET) require special monitoring and an appropriate treatment, The object of this case report is to highlight the different clinical presentation of the same lesion in the same patient and the difficulties in decisions&#8217...

Introduction: Cushing’s disease (CD) is reported in 60-70% of all patients with Cushing’s syndrome (CS), but occurs only in approximately 33% of the reported CS cases in pregnancy. Nevertheless, despite its rarity, pregnancy in patients with CS can be troublesome because of the risk of maternal-fetal complications.Observation: A 28-year-old female patient was referred to our endocrinology department for a suspected CS with morphological alter...

Introduction: Leydig cell tumors (LCTs) are uncommon neoplasms arising from gonadal stroma, accounting for 1–3% of all testicular tumors in adults. The etiology of LCT remains unclear. About 25% of LCTs secrete predominantly estrogens, which produce gynecomastia.Observation: We report a case of a 53-year-old male patient who sought evaluation for bilateral gynecomastia. He had a long-term use of amitriptyline and benzodiazepine. The physical examin...

Introduction: Primary and nonsuppressible hypersecretion of aldosterone is an increasingly recognized, but still underdiagnosed, cause of hypertension. Our objective is to determine the evolution features of primary aldosteronism (PA) patients.Patients and Methods: Retrospective study of 17 patients with PA confirmed biochemically and histologically when operated.Results: The mean age was 41.9 ± 9.3 years at PA diagnosis, and ...

IntroductionTurner syndrome (TS) is among the most common chromosomal abnormalities in females, resulting from structural or numeric abnormalities in the X chromosome. Autoimmune disorders, especially thyroid diseases have a high prevalence among these patients. Usually Hashimoto’s thyroiditis (HT) is the most frequent one, whilst the association between this syndrome and Graves’ disease (GD) has been less often reported. Here we report a case ...

IntroductionWerner syndrome (WS) is a rare genetic disorder that displays clinical features suggestive of accelerated aging. Also known as adult progeria, it is caused by mutations in the WRN gene, which encodes a RecQ DNA helicase. Primary characteristics of this syndrome are progeroid changes of hair, bilateral cataract, atrophic skin, soft-tissue calcification, bird-like face, abnormal voice and many others features. Here we report 5 patients...

Introduction: Pheochromocytoma in pregnancy is rare with an incidence of 0.007%. A timely diagnosis is essential since fetal and maternal mortality depends on the early treatment. Our object is to report a pheochromocytoma diagnosed in a patient at the beginning of the pregnancy and to highlight the particularity in the therapeutic care.Case presentation: A 32-year-old female patient was admitted to our endocrinology department for exploration of palpita...